Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>

Biological objectives and you can pharmacology out of curcumin

Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin is the big element of brand new yellow color off turmeric, an enthusiastic Indian liven that’s obtained from the fresh new rhizome of exotic plant Curcuma longa, which belongs to the Zingiberaceae family unit members. Contained in this part, we talk about the pharmacological facts out-of curcumin and you may mention new molecular basics for these issues. We next remark the latest shown and you can possible logical spends regarding curcumin. Curcumin is known usually as the a curative representative, however, the mechanism out-of step is actually in depth. The newest pharmacological results of curcumin seem to be the consequence of a beneficial synergism away from systems of poor biochemical connections which have multiple biological targets for the interrelated signaling routes. Such purpose include nutrients such cyclooxygenase, lipoxygenase and necessary protein kinases, and you will transcription products for example NF-?B, STAT and naviger til webstedet you may Nrf2. Modulation of those molecules influences downstream affectors that make new antiinflammatory, antioxidant, chemopreventive, anticancer, and antimicrobial things of curcumin. Such consequences had been tested when you look at the clinical examples of curcumin getting problems and you can inflammatory ailment, cancer, Alzheimer condition, aerobic ailment, and you will all forms of diabetes. The new examples purchased changeable dosage from curcuminwith various other wavelengths and years, to your general conclusion one to large dosage regarding curcumin on number of g must see healing consequences. Find out more

Curcumin: Synthesis, Emerging Role when you look at the Serious pain Administration and you can Wellness Implications

Publication Part Types of bush-derived pharmaceuticals with end up being the notice out of continuing and you will rapid search and you will innovation focus has actually, at this point, already been quite scarce. After years, the last twenty years had been characterized by a beneficial 100-bend upsurge in just how many medical blogs had written per year you to definitely was off importance to the access to curcumin in the biomedicine. Find out more

Construction, synthesis and you will physiological affairs out of curcumin prodrugs

Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has many potential pharmacological outcomes and could enjoys therapeutic programs in several situation says, given that discussed in more detail in the earlier section. However, the potential clinical efficacy from curcumin is bound of the the physicochemical services regarding poor water solubility and you may imbalance, which result in reasonable bioavailability. Prodrugs from curcumin render an effective way to update of biopharmaceutical and you can pharmacokinetic functions, that will enable it to be exploitation of one’s pharmacological outcomes of curcumin. Contained in this chapter, we earliest feedback brand new physicochemical and you may pharmacokinetics regarding curcumin. We after that identify the appearance of curcumin prodrugs having increased drinking water solubility and you may improved chemical balances which may be translated back to 100 % free curcumin abreast of bioactivation into the vivo. We focus on latest profits in this region, having a concentrate on the framework, synthesis and you may comparison out of prodrugs according to promoieties including amino acids, efas, nucleic acids, dicarboxylic acids, and you may polymeric materials like hyaluronic acid and you will polyethylene glycol. So it part gets the basis for optimization of your physicochemical and you will biopharmaceutical attributes and also the physiological affairs away from curcumin prodrugs, to your purpose playing with of these curcumin types from inside the clinical software. Read more